Dr Panagiotis Liakos Assistant Professor of Medical Biochemistry Tel. 2410 685579 e-mail: pliakos@med.uth.gr

Studies:

1994. Graduated from Joseph Fourier I University, Grenoble France Department of Biology (Maitrise of Biochemistry)

1995. Master in Molecular and Cellular Biology (D.E.A specialized in physiopathology) from Joseph Fourier I University, Grenoble France.

1999. PhD in Molecular and Cellular Biology from the Biological, Medical and Pharmaceutical School of Joseph Fourier I University, Grenoble France July, Laboratory of Biochemistry and Cellular Endocrine Regulation- ΙΝSΕRΜ244 unit, Department of Molecular and Structural Biology of Grenoble Nuclear Research Center.

2001-2003. Postdoctoral Fellow, Department of Biological Chemistry Medical School Aristotle University Thessaloniki, Greece.

Employment:

2003 Lecturer in Medical Biochemistry, Department of Biochemistry Mediacal School of Thessaly.
2008 to today Assistant Professor in Medical Biochemistry, Department of Biochemistry Medical School of Thessaly.

Research interests:

• The mechanism of Ηypoxia inducible factor-2α (ΗIF-2α) regulation and his role in cellular homeostasis.
• The contribution HIF-2α and HIF-1α in the cellular response of various forms physiologic or pathological stress.
• Mechanisms of healthy and cancer cells in oxidative stress.

Selected Publications

1. LIAKOS P., BOURMEYSTER N., DEFAYE G., CHAMBAZ E.M. & BOTTARI S. (1997). Angiotensin II AT1 and AT2 receptors both inhibit bFGF induced proliferation of bovine adrenocortical cells. Am. J. Physiology 273: C1324-1334.(pubmed)

2. CHABRE O, LIAKOS P, VIVIER J, CHAFFANJON P, LABAT-MOLEUR F, MARTINIE M., BOTTARI S, BACHELOT I,  CHAMBAZ E.M, DEFAYE G.& FEIGE J.J. (1998). Gastric inhibitory peptide (GIP)-dependent adrenal Cushing adenoma: insights into hormonal control of adrenocortical tumorigenesis. J. Clin. Endocrinol. Metab. 83:3134-3143.(pubmed)

3. LIAKOS P., CHAMBAZ E.M., FEIGE J.J. & DEFAYE G. (2000) Expression and regulation of melanocortin receptors 5 (MC5-R) in the bovine adrenal cortex. Mol Cell Endocrinol  159: 99-107.(pubmed)

4. GAILLARD I, KERAMIDAS M, LIAKOS P, VILGRAIN I., FEIGE J.J. & VITTET D. (2000) ACTH-regulated expression of vascular endothelial growth factor in adult bovine adrenal cortex: A possible role in the maintenance of the microvasculature. J. Cell. Physiol.  Nov 185 (2): 226-34.(pubmed)

5. CHABRE O., PORTRAT-DOYEN S., CHAFFANJON P., VIVIER J., LIAKOS P., LABAT-MOLEUR F., CHAMBAZ E., MOREL Y. AND DEFAYE G. (2000) Laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1. J. Clin. Endocrinol. Metab. Nοv 85 (11): 4060-8.(pubmed)

6. LIAKOS P., LENZ D., BERNHARDT R., FEIGE JJ., DEFAYE G. (2003) Transforming Growth factor β1 inhibits aldosterone and cortisol production in human adrenocortical carcinoma cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression. J. Endocrinol 176(1)69-8(pubmed)

7. TRIANTAFYLLOU, A., LIAKOS, P., TSAKALOF, A., GEORGATSOU, E., SIMOS, G. and BONANOU, S. (2006) Cobalt induces hypoxia-inducible factor-1α in HeLa cells by an iron-dependent, but ROS-, PI-3K- and MAPK-dependent mechanism. Free Radical Research 40(8):847-856(pubmed)

8. KONSTANTINIDIS D., KOLIAKOS G., VAFIA K., LIAKOS P., BANTEKAS C., TRACHANA V.AND KALOYIANNI M. (2006) Inhibition of the Na+-H+ exchanger isoform-1 and the extracellular signal-regulated kinase induces apoptosis: a time course of events. Cell Physiol Biochem. 2006;18(4-5):211-22.(pubmed)

9. TRIANTAFYLLOU A., P. LIAKOS, A. TSAKALOF, G. CHACHAMI, E. PARASKEVA, P-A. MOLYVDAS, E. GEORGATSOU, G. SIMOS, and S. BONANOU (2007) The flavonoid quercetin induces HIF-1α expression and inhibits cell proliferation by depleting iron. Free Radic Res. 2007; 41(3):847-56.(pubmed)

10. CHACHAMI G., A. HATZIEFTHIMIOU, P. LIAKOS, S. BONANOU, P.- A. MOLYVDAS, G. SIMOS AND E. PARASKEVA. (2007) Exposure of differentiated Airway Smooth Muscle cells to serum stimulates both induction of Hypoxia Inducible Factor-1α and airway responsiveness to Ach. Am J.Physiol: Lung Cell Mol Biol 293,913-22(pubmed)

11. KADITIS A, ALEXOPOULOS E, NTAMAGKA G, CHAIDAS K, KARATHANASI A, GOUGOURA S, PAPATHANASIOU AA, LIAKOS P, ZINTZARAS E, GOURGOULIANIS K. (2010) Serum nitrite and nitrate levels in children with obstructive sleep-disordered breathing. Sleep Med.; 11(3):258-62(pubmed)

12. GOUGOURA S, LIAKOS P,. KOUKOULIS G.N. (2010) Effect of CRH on NO bioavailability, ROS production, and antioxidant defense systems in endothelial EAhy926 cells  Free Radical Research. In Press(pubmed)

CV short (.pdf)