Ξηρομερήσιου Γεωργία

Xiromerisiou Georgia

Personal information

E-mail: georgiaxiromerisiou@gmail.com geoksirom@med.uth.gr

Title

Assistant Professor of Neurology, School of Medicine, University of Thessaly

Education/Employment

  • University of Thessaly Medical School Degree 2000
  • Thesis 2007 Title: Study of polymorphisms of various genes in patients with Parkinson's disease
  • Research position at the Laboratory of Neurogenetics, National Research Institute, NIH, Bethesda, Maryland, USA Research fellowship 2004-2005
  • Neurology specialty 2005-2009 AHEPA Hospital
  • Clinical training in movement disorders at the National Hospital for Neurology and Neurosurgery, UCL, London Clinical fellowship 2009-2011
  • Research position at the Institute of Neurology, Department of Molecular Neuroscience Research fellowship 2010-2011
  • Research position in the neurogenetics section of the Biomedical Technological InstituteMember of the research team in neurogenetics Section of the Institute of Biomedical Technology CERETETH (Centre for research and Technology-Thessaly) 2011-2015
  • Supervisor of Neurology at the Neurological Clinic of Papageorgiou Hospital 2011-2017
  • Research Position at the Laboratory of Neurogenetics 2017 Laboratory of Neurogenetics, National Institute on Aging, at the National Institutes of Health NIH, Bethesda, Maryland,

Selected publications

Selected peer-reviewed publications 54 peer-reviewed Publications can be found in http://www.ncbi.nlm.nih.gov/pubmed/?term=xiromerisou

h- index scopus: 28

  • Bettencourt C, Salpietro V, Efthymiou S, Chelban V, Hughes D, Pittman AM, Federoff M, Bourinaris T, Spilioti M, Deretzi G, Kalantzakou T, Houlden H, Singleton AB, Xiromerisiou G. Genotype-phenotype correlations and expansion of the molecular spectrum of AP4M1-related hereditary spastic paraplegia. Orphanet J Rare Dis. 2017 Nov 2;12(1):172. doi: 10.1186/s13023-017-0721-2. PubMed PMID: 29096665.
  • Nalls MA, ……Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, HeutinkP, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014 Sep;46(9):989-93.
  • Nalls MA et al International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Disease meta-analysis consortium. NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiol Aging. 2015Mar;36(3):1605.
  • Xiromerisiou G et Identical twins with Leucine rich repeat kinase type 2 mutations discordant for Parkinson's disease. Mov Disord. 2012 Sep 1;27(10):1323.
  • Michelakakis H, Xiromerisiou G, Dardiotis E, Bozi M, Vassilatis D, Kountra PM, Patramani G, Moraitou M, Papadimitriou D, Stamboulis E, Stefanis L, Zintzaras E, Hadjigeorgiou GM. Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease. Mov Disord. 2012 Mar;27(3):400-
  • Xiromerisiou G, et al THAP1 mutations in a Greek primary blepharospasm series. Parkinsonism Relat Disord. 2013 Mar;19(3):404-5
  • Xiromerisiou G et al THAP1 mutations and dystonia phenotypes: genotype phenotype correlations. Mov Disord. 2012 Sep 1;27(10):1290-4.
  • Heckman MG, Elbaz A, Soto-Ortolaza AI, Serie DJ, Aasly JO, Annesi G,…………, Wirdefeldt K, Wszolek ZK, Wu RM, Xiromerisiou G, Maraganore DM, Farrer MJ, Ross OA; Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium. Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants. Neurobiol Aging. 2014 Jan;35(1):266.e5-14
  • Moraitou M, Hadjigeorgiou G, Monopolis I, Dardiotis E, Bozi M, Vassilatis D, Vilageliu L, Grinberg D, Xiromerisiou G, Stefanis L, Michelakakis H. β-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease. Mol Genet Metab. 2011 Sep-Oct;104(1-2):149-52.
  • Xiromerisiou G et al Lack of association of the UCHL-1 gene with Parkinson's disease in a Greek cohort: a haplotype-tagging approach. Mov Disord. 2011 Aug 15;26(10):1955-7.

Selected research projects

  1. Identification of genes for Parkinson's disease in an isolated Greek community and a Greek population cohort. Grant from Parkinson's Disease Foundation-USA. Duration: 2011-2013. Grant award: PDF-IRGP-1102. Total amount: 150,000 dollars. Coordinator-PI: G. Xiromerisiou
  2. Research Committee University of Thessaly (code 2845), 2005-2010: Genetic basis of Neurological Diseases.Role: Investigator
  3. A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy The Tau Restoration on PSP (TAUROS) study was a double-blind, placebo-controlled, randomized trial to assess the efficacy, safety, and tolerability oftideglusib, a GSK- 3 inhibitor, as potential treatment for PSP
  4. Michael J. Fox Foundation for Parkinson's disease. Maraganore D (Global – PI) 2005-2006 Independent validation study (“MJFF Validation Study”) of designated single-nucleotide polymorphisms (SNPs) previously associated with Parkinson's disease in the Michael J. Fox Foundation-funded project “High-resolution whole genome study to determine the genetic loci of Parkinson's disease” Role: Investigator
  5. FLEX mobile Dementia Assistant: funded by FINODEX http://www.finodex-project.eu/  Role: Scientific Advisor
  6. Retrospective and Prospective Cohort Study of Adult Patients Suspected of Niemann-Pick Type C Disease Role: Principal Investigator

 

 

 

Department: PMS "Thrombosis and Antithrombotic Treatment"
Designation: Assistant Professor