EVIDENCE-BASED MEDICINE AND META-ANALYSES

EVIDENCE-BASED MEDICINE AND META-ANALYSES

EVIDENCE-BASED MEDICINE AND META-ANALYSES

Lesson Code: BE0401

Professor in charge: Ilias Zintzaras, Professor

Other Teachers: Doxani Chrysoula, Theodoros Brotsis

ECTS: 2.00

Type|Type of Course: OP | SCIENTIFIC AREA

Teaching Semester: 14th Semester

Hours per week: 2 hours

Total Time (Teaching Hours + Student Workload) 54 Hours

Prerequisites: NO

Language of Instruction: Greek

Available for Erasmus: YES

Semester Lectures: Coming Soon…

Teaching Method: LECTURES Face to face in the Department's IT lab and in the auditorium

COMPULSORY PRESENTATION NO

Lectures in powerpoint format

In each lesson, laboratory exercises are carried out on a computer

Use of T.P.E. in communication with students (website, e-mail, etc.)


Evaluation Method:

The evaluation of the students is done in Greek with a written assignment.


Objective Objectives/Desired Results: The general purpose of the course is to introduce students to the principles of Evidence-Based Medicine and the methodology of Meta-Analyses and to enable them to evaluate and interpret the results of published clinical studies with the ultimate goal of applying them in clinical practice.

The specific objectives of the course are specialized in the following intended learning outcomes:

Upon successful completion of the course, the student will be able to:

He/she will be able to use the acquired knowledge in order to:

  • Understand the types of clinical trials
  • To systematically search for clinical studies from information sources (e.g. Cochrane Library, etc.)
  • To methodologically evaluate clinical studies as well as their meta-analyses
  • Process and extract clinical trial data
  • To meta-analyze the results of clinical studies, to present and interpret them
  • To evaluate and meta-analyze the data of diagnostic studies
  • To become familiar with the decision-making process based on statistical data

General Skills

Search, analysis and synthesis of data and information, using the necessary technologies

Decision making

Autonomous work

Teamwork

Work in an international environment

Promotion of free, creative and inductive thinking


Course URL : http://biomath.med.uth.gr

Course Description: • Categories of medical research and the pyramid of indications.
• Search for clinical studies and sources of clinical information (eg Cochrane Library, etc.).
• Critical methodological/statistical evaluation of clinical studies.
• Clinical Review Methodology 1: checking for published reviews, formulating the clinical question and developing the systematic review protocol and planning the search and conducting a literature search.
• Clinical Review Methodology 2. Selection of studies, data extraction and interpretation of results
• Meta-analysis 1: Synthesis of results of clinical studies when there is no heterogeneity between studies.
• Meta-analysis 2. Calculation and investigation of heterogeneity between studies..
• Meta-analysis 3: Synthesis of results of clinical studies when there is heterogeneity between studies.
• Meta-analysis 4: Checking for errors,
• Evaluation of the quality of the studies with the CONSORT, STROBE and PRISMA tools.
• Decision making with a statistical approach.
• Diagnostic studies 1: diagnostic indicators and assessment of study quality based on the STARD questionnaire.
• Diagnostic studies 2: systematic review and meta-analysis

Recommended reading: Teaching notes are distributed:

  • Ilias Zintzaras (2015) "Methodology of meta-analyses",

PMS "Biomedical Research Methodology, Biostatistics and Clinical Bioinformatics",

Department of Medicine, University of Thessaly

  • Ilias Zintzaras and Doxani Chrysoula (2015) "Evidential and translational medicine",

PMS "Biomedical Research Methodology, Biostatistics and Clinical Bioinformatics"

Department of Medicine, University of Thessaly

In addition, the following bibliography is indicated

Anne Whitehead, Meta-Analysis Of Controlled Clinical Trials, Wiley, 2013

Cochrane Handbook for Systematic Reviews of Interventions version 6.2 The Cochrane Collaboration. Cochrane, 2021


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