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CLINICAL BIOCHEMISTRY

CLINICAL BIOCHEMISTRY

CLINICAL BIOCHEMISTRY

COURSE CODEΒΕ0711

COURSE INSTRUCTORPanagiotis Liakos, Professor 

CO-INSTRUCTORSG. Simos, I. Mylonis, G. Chachami, T. Sideri

ECTS:2.00

COURSE TYPE

EL | BACKGROUND

TEACHING SEMESTERSPRING SEMESTER

WEEKLY TEACHING HOURS: 2 HOURS

Total Time (Teaching Hours + Student Workload)54 HOURS

PREREQUIRED COURSES:

NO

LANGUAGE OF TEACHING AND EXAMSGREEK

AVAILABLE TO ERASMUS STUDENTSNO

SEMESTER LECTURES:DETAILS/LECTURES

TEACHING AND LEARNING METHODS :

Face to Face:

Teaching of “Clinical Biochemistry” consists of lectures and laboratory practicals.

Presence in 2/3 of theLectures is mandatory.

Information and Communication Technologies are used for the preparation of the lecture material, the online information and provision of supplementary learning material to students.

Specifically:

  • Common software (e.g. MS powerpoint) is used to prepare lecture material and display slides and videos.
  • The slides of each lecture as well as scientific articles made available electronically and online to students through the e-class system of our university.
  • Common software (e.g. MS excel) is used to statistically process student assessment.

Announcements, information etc are available online via e-class.

Communication is also done via e-mail.

  • Information about the course, instructors and their research interests and in general the Laboratory of Biochemistry of the Faculty of Medicine are available online on the Laboratory website http://www.med.uth.gr/biochemistry/index.html

STUDENT EVALUATION

The language of assessment is English. 

Evaluation methods. 

The examination of the course is based on the work that the students will prepare and present. 

Final Grade

The final grade of the course 100% is calculated from the work that the students will be given to develop..


Objective Objectives/Desired Results:

Aims of the course

The course of Clinical Biochemistry is the essential tool for studying the main human organs and systems that every physician needs to know in daily practice. This course presents the practical biochemical tests, how to use and process biochemical data as well as the diagnostic value of the biochemical analyses in specific clinical situations. Finally, it helps to understand the basic mechanisms of biochemical disorders so that they can be utilized by the physician for diagnosis and treatment.

The course is the main link between the theoretical knowledge acquired by the Student with Biochemistry I and II and the application of his knowledge in clinical practice. It also prepares the student with the knowledge provided in specialties such as Microbiology, Endocrinology, Pathology, Pediatrics and Oncology. 

After the successful completion of this course, the students will be able to:

  • understand the regulation of the biochemical functions of the human body at the molecular, cellular and systemic level.
  • know the biochemical specificity of various tissues and systems.
  • distinguish the laboratory pathological picture from the normal one and propose a diagnosis for the treatment of basic metabolic diseases.
  • analyzes and processes the results of basic biochemical analyses

General Abilities

  • Research, analysis and synthesis of data and information, using the necessary technologies Adaptation to new situations
  • Decision making
  • Autonomous work Teamwork
  • Working in an international environment
  • Work in an interdisciplinary environment
  • Exercise criticism and self-criticism
  • Promoting free, creative and inductive thinking

Course URL :http://eclass.uth.gr/eclass/courses/MED_U_177

Course Description:

Lecture contents

Lecture 1: Biochemical tests: reliability, diagnostic value, quality control and interpretation (2 hours)

Lecture 2: Enzymes of diagnostic purpose and biochemical control of organ function (2 hour)

Lectures 3: Therapeutic Drug Monitoring and Chemical Aspects of Toxicology (2 hours)

Lectures 4: Inherited Metabolic Diseases (2 hours)

Lectures 5: Disorders of Haemoproteins, Porphyrins and Iron (2 hours)

Lectures 6: Plasma proteins: metabolism, definition, disorders, hereditary diseases (2 hours)

Lecture 7: Biochemical control of hormone function (2 hours)

Lectures 8: Carbohydrates: metabolism, definition, disorders, diabetes mellitus (2 hours)

Lectures 9: Lipids, Lipoproteins: definition, hyperlipoproteinaemia, coronary disease (2 hours)

Lecture 10: Sodium, Potassium-homeostasis and definition (2 hours)

Lecture 11: Biochemical changes of malignant disease: tumour markers (2 hours)

Lectures 12: Biochemical control of kidney function (2 hours)

Lecture 13: Analytical methods and operation of the Biochemistry laboratory

(Visit General University Hospital of Larissa)

 
Recommended reading:

Lecture Material

Main suggested textbooks:

  1. Nessar Ahmed: Clinical Biochemistry, Second edition
  2. Gaw Allan, Cowan Robert A., O’ Reilly Dennis S. J., Stewart Michael J., Shephard James. Clinical Biochemistry, an illustrated colour text

Further reading:

Marshall W.J. & S.K. Bangert: Clinical Chemistry, Sixth edition Elsevier

 Berg, Tymoczko & Stryer: BIOCHEMISTRY (7th Edition)

Ferrier R. D.: Lippincott’s Illustrated Reviews: BIOCHEMISTRYm6th edition, Lippincott Williams & Wilkins, USA

Marshall W.J. & S.K. Bangert: Clinical Chemistry

Branden C. & J. Tooze: Introduction to Protein Structure

Devlin Τ. Μ.: Biochemistry with Clinical correlations Part I and II

M. A. Lieberman & A. Marks: Marks Basic Medical Biochemistry: A clinical approach (4th Edition)

Koolman J. & K.-H. Roehm: Colour Atlas of Biochemistry

Relevant Scientific Journals:

Annual Review of Biochemistry

Archives of Biochemistry and Biophysics

Biochemical and Biophysical Research Communications

Biochemical Journal

Biochemistry

Biochemistry and Cell Biology

Biochimica et Biophysica Acta

Biochimie

Biological Chemistry

Cell

Cell Metabolism

Cellular Physiology and Biochemistry

Cellular Signalling

Cellular and Molecular Life Sciences

Clinical Biochemistry

Critical Reviews in Biochemistry and Molecular Biology

EMBO Journal

FEBS Letters

Free Radical Biology and Medicine

Free Radical Research

The International Journal of Biochemistry & Cell Biology

Journal of Biochemistry

Journal of Biological Chemistry

Journal of Cell Science

Journal of Cellular Biochemistry

Journal of Lipid Research

Journal of Medical Biochemistry

Journal of Molecular Biology

Journal of Molecular Medicine

Methods in Enzymology

Molecular and Cellular Biology

Molecular Cell

Nucleic Acids Research

Protein Science

RNA

The FEBS Journal

Trends in Biochemical Sciences

 


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